How do I even begin to troubleshoot this?

Steam games work fine. Linux-native games work fine. In Wine games, the game video seems to pause for 1.5s, then plays for 2.5s. Audio is unaffected. It seems like the frames are lagged, not lost; when video resumes, the "missing" frames play back very quickly, like the video is "catching up". This happens even in the games' launcher windows before 3D rendering or GPU load occurs. Mouse pointer does not lag or pause.

This happens in both wine-ge 8.26 and WineHQ Staging 9.22.

The weirdest thing is that without changing any settings, the same games will run fine about 1 out of 20 launches.

Thanks for any input.

[System]
OS:              LMDE 6 faye
Arch:            x86_64
Kernel:          6.1.0-28-amd64
Desktop:         X-Cinnamon
Display Server:  x11

[CPU]
Vendor:          GenuineIntel
Model:           Intel(R) Core(TM) i7-6700K CPU @ 4.00GHz
Physical cores:  4
Logical cores:   8

[Memory]
RAM:             31.3 GB
Swap:            31.3 GB

[Graphics]
Vendor:          NVIDIA Corporation
OpenGL Renderer: NVIDIA GeForce GTX 980 Ti/PCIe/SSE2
OpenGL Version:  4.6.0 NVIDIA 535.183.01
OpenGL Core:     4.6.0 NVIDIA 535.183.01
OpenGL ES:       OpenGL ES 3.2 NVIDIA 535.183.01
Vulkan:          Supported

INFO     2024-11-27 00:05:40,331 [startup.init_lutris:173]:Starting Lutris 0.5.12
DEBUG    2024-11-27 00:05:40,360 [xrandr._get_vidmodes:16]:Retrieving video modes from XrandR
INFO     2024-11-27 00:05:40,524 [startup.check_driver:57]:Using NVIDIA drivers 535.183.01 for x86_64
INFO     2024-11-27 00:05:40,525 [startup.check_driver:61]:GPU: NVIDIA GeForce GTX 980 Ti
INFO     2024-11-27 00:05:40,525 [startup.check_driver:77]:GPU: 10DE:17C8 19DA:1396 (nvidia drivers)
DEBUG    2024-11-27 00:05:40,674 [lutriswindow.update_store:448]:Showing 3 games
INFO     2024-11-27 00:05:40,682 [startup.update_runtimes:218]:Startup complete
INFO     2024-11-27 00:05:54,373 [runner.use_runtime:299]:Runtime disabled by system configuration
INFO     2024-11-27 00:05:54,463 [runner.use_runtime:299]:Runtime disabled by system configuration
INFO     2024-11-27 00:05:54,489 [runner.use_runtime:299]:Runtime disabled by system configuration
DEBUG    2024-11-27 00:05:54,489 [xrandr._get_vidmodes:16]:Retrieving video modes from XrandR
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:DISABLE_LAYER_AMD_SWITCHABLE_GRAPHICS_1="1"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:__GL_SHADER_DISK_CACHE="1"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:__GL_SHADER_DISK_CACHE_PATH="/home/myusername/Games/phantasy-star-online-blue-burst"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:VK_ICD_FILENAMES="/usr/share/vulkan/icd.d/nvidia_icd.json"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINEDEBUG="-all"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:DXVK_LOG_LEVEL="none"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINEARCH="win64"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINE="/home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/bin/wine"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINE_MONO_CACHE_DIR="/home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/mono"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINE_GECKO_CACHE_DIR="/home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/gecko"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:GST_PLUGIN_SYSTEM_PATH_1_0="/home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/lib64/gstreamer-1.0/:/home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/lib/gstreamer-1.0/"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINEPREFIX="/home/myusername/Games/phantasy-star-online-blue-burst"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINEESYNC="1"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINEFSYNC="1"
DEBUG    2024-11-27 00:05:54,654 [command.start:141]:WINE_FULLSCREEN_FSR="1"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:DXVK_NVAPIHACK="0"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:DXVK_ENABLE_NVAPI="1"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:PROTON_BATTLEYE_RUNTIME="/home/myusername/.local/share/lutris/runtime/battleye_runtime"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:PROTON_EAC_RUNTIME="/home/myusername/.local/share/lutris/runtime/eac_runtime"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:WINEDLLOVERRIDES="dinput8=n,b;d3d10core,d3d11,d3d12,d3d9,d3dcompiler_33,d3dcompiler_34,d3dcompiler_35,d3dcompiler_36,d3dcompiler_37,d3dcompiler_38,d3dcompiler_39,d3dcompiler_40,d3dcompiler_41,d3dcompiler_42,d3dcompiler_43,d3dcompiler_46,d3dcompiler_47,d3dx10,d3dx10_33,d3dx10_34,d3dx10_35,d3dx10_36,d3dx10_37,d3dx10_38,d3dx10_39,d3dx10_40,d3dx10_41,d3dx10_42,d3dx10_43,d3dx11_42,d3dx11_43,d3dx9_24,d3dx9_25,d3dx9_26,d3dx9_27,d3dx9_28,d3dx9_29,d3dx9_30,d3dx9_31,d3dx9_32,d3dx9_33,d3dx9_34,d3dx9_35,d3dx9_36,d3dx9_37,d3dx9_38,d3dx9_39,d3dx9_40,d3dx9_41,d3dx9_42,d3dx9_43,dxgi,nvapi,nvapi64=n;winemenubuilder="
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:WINE_LARGE_ADDRESS_AWARE="1"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:game_name="Phantasy Star Online: Blue Burst"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:PYTHONPATH="/usr/lib/lutris:/usr/games:/usr/lib/python311.zip:/usr/lib/python3.11:/usr/lib/python3.11/lib-dynload:/usr/local/lib/python3.11/dist-packages:/usr/lib/python3/dist-packages:/usr/lib/python3.11/dist-packages"
DEBUG    2024-11-27 00:05:54,655 [command.start:141]:LUTRIS_GAME_UUID="f9abc50e-f22b-4514-a8aa-64ff8bf001bc"
Discord ID: 505152925115482112
INFO     2024-11-27 00:05:54,671 [game.start_game:586]:Discord RPC Disabled or Discord APP ID Not Present
Started initial process 18795 from gamemoderun /home/myusername/.local/share/lutris/runners/wine/wine-ge-8-26-x86_64/bin/wine /home/myusername/Games/phantasy-star-online-blue-burst/drive_c/EphineaPSO/online.exe
Start monitoring process.
gamemodeauto: 
fsync: up and running.
wine: RLIMIT_NICE is <= 20, unable to use setpriority safely
Monitored process exited.
Initial process has exited (return code: 0)
Exit with return code 0
DEBUG    2024-11-27 00:09:22,020 [command.on_stop:195]:Process 18793 has terminated with code 0
DEBUG    2024-11-27 00:09:22,906 [game.beat:693]:Game thread stopped
WARNING  2024-11-27 00:09:22,906 [game.on_game_quit:730]:Game still running (state: running)
INFO     2024-11-27 00:09:22,906 [game.stop:704]:Stopping Phantasy Star Online: Blue Burst (wine)
DEBUG    2024-11-27 00:09:22,906 [game.stop_game:664]:Phantasy Star Online: Blue Burst (wine) has run for 208 seconds
DEBUG    2024-11-27 00:09:22,922 [game.on_game_quit:748]:Phantasy Star Online: Blue Burst stopped at Wed, 27 Nov 2024 00:09:22
DEBUG    2024-11-27 00:09:22,922 [game.save:299]:Saving Phantasy Star Online: Blue Burst (wine) with config ID phantasy-star-online-blue-bur-ephinea-and-addon-pl-1732000393
DEBUG    2024-11-27 00:09:37,374 [xrandr._get_vidmodes:16]:Retrieving video modes from XrandR
DEBUG    2024-11-27 00:09:37,518 [xrandr._get_vidmodes:16]:Retrieving video modes from XrandR
DEBUG    2024-11-27 00:09:37,662 [xrandr._get_vidmodes:16]:Retrieving video modes from XrandR
DEBUG    2024-11-27 00:09:37,828 [application.show_window:328]:Showing window PreferencesDialog{}