Driving in Japan with the wheel on the right side. The first time I did that last year I drove on the wrong side of the road about 5 times and got a shock every time when I saw all the ghost drivers just to quickly realize that it's me who is driving the wrong way. This year it only happened one time, so my brain seems to adapt to that better and better.
I haven't tried it myself but id believe that for me the greatest challenge would be the gear shift with the left hand!
thankfully the pedal arrangement is the same.