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New Vaccine Can Completely Reverse Autoimmune Diseases Like Multiple Sclerosis, Type 1 Diabetes, and Crohn’s Disease (scitechdaily.com)

submitted 1 year ago by [email protected] to c/[email protected]

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Researchers from Pritzker Molecular Engineering, under the guidance of Prof. Jeffrey Hubbell, demonstrated that their compound can eliminate the autoimmune response linked to multiple sclerosis. Researchers at the University of Chicago's Pritzker School of Molecular Engineering (PME) have developed

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[–] [email protected] 208 points 1 year ago (49 children)

I've been following cures like this for years. There are three candidates in phase 2 trials right now that appear to work, they're mostly figuring out the doses needed and there's a big question on how long they last. Hopefully permanent but we don't know for sure.

Diabetics have just been so beaten down by this whole thing. I was told the cure was 10 years away 40 years ago. Even if the technology described here works we could be another 15 years before we see it. Researchers said it could be here as soon as 5 years, which is true if unrealistically optimistic. I believe the cure is coming but I'm not holding my breath until I'm actually in front of a doctor about to receive the cure whatever it happens to be.

[–] [email protected] 15 points 1 year ago (2 children)

A few people asked for more information about these trials that I referred to above. In theory if you can cure one autoimmune disease you should be able to use the same method to cure any of them. Obviously we don't know that for certain and diseases like Diabetes has the extra step of inducing the growth of new beta cells to produce insulin (more on that below)

That said, the three trials I referred to are Celiac specific. I have this and T1D so those are the two I've been following most closely, but I definitely dive into news on ms or any of the other autoimmune diseases.

Note: all of these entered phase 2 this year. They are in the EARLY EARLY stages of that phase, so we should see results in 2025/26 for these. I am also ignoring any trial not in phase 2. Also note that several diabetes and ms cures are essentially variants of these, and many of them are running in parallel.

KAN-101: This is from Anokion and happens to have a trial in my area, hence it's the one I know the most about. This one works by targetting the liver where the relevant immune cells are produced. Even in their phase 1 trial they found that patients had a dose dependent reduction in IL-1 (a cytokine that your body releases in the presence of gluten if you're celiac). As with all these trials they need to determine what dose is needed to be a full cure and is it permanent?

TAK-101: This is an MS cure that was adapted for celiac disease, originally developed by ImmunisanT. They also have several other variants of this one, including T1D. Unfortunately their website seems to be down. Takeda is handling the clinical trials here and last I heard they're waiting for the celiac results before pushing forward with the others, but they expect them to move quickly at that point. Here's a video by one of the researchers behind this.

TPM502: I know the least about this one, it's from Topas Therapeutics and they recently announced the start of phase 2 trials in Finland, Norway, the Netherlands and Sweden. [more]

I should emphasize that there is no guarantee any of these treatments will work and everyone is tired of the latest "breathrough" that we never hear about again. Some of the trails above had to go back to the drawing board after hitting phase 2, TAK-101 is a newer generation of "Nexxvax" which if you google that you'll find articles about its cancellation.

Then Diabetes has the problem of beta cells needing to be restored or replaced. That's looking feasible either by transplanting adult cells, stimulating the growth of new ones using stem cells or a similar concept. One proposal hides the beta cells from your immune system entirely inside a scaffold. That last one is more of a new treatment than a cure, but it definitely beats what we have now.

The good news is that work IS being done in this area, progress is being made, and I know at least with KAN-101 they have demonstrated it showing results. The cure is coming. Even if most or all of these trails fails the fact that they've seen the results that they have is still really good news.