Gaming

The Last of Us: Part II !

Great list from @[email protected], just a few more:
Gris is an absolute gem.
The A Plague Tale duology is also up there (with Requiem being my favourite game of all time, so I'm extremely biased, sorry / not sorry :D).

Alien Isolation

Returnal.

Mirror's Edge is a good one I haven't seen mentioned yet. A bit older by this point but it was a fun one.
Transistor is another great one. The gameplay was fine but the art and sound is incredible.

It's older, but The Longest Journey is good. Unfortunately, the final game in the series kinda sucks.

While it's an ensemble, most people would agree that the main character of Final Fantasy VI is a woman—they just might disagree about which woman is the lead.

I also liked the first Xenosaga game, but again, it's a series that goes pretty badly downhill.

Can I suggest some great novel games?

**VA-11 HALL-A: Cyberpunk Bartender Action **

• play as a bartender and change outcomes of stories by providing different drinks

Fatal Twelve

• death game, mystery, lesbian couple as main character, one of the best

beyond good and evil is great

Jade from Beyond Good and Evil.

Ms Pac Man obviously

Whoa whoa whats wrong with Senua?

Night in the Woods is objectively the best game ever made by any measure. Tacoma and Gone Home are amazing too.

I mean I dunno, it depends on what kind of games you like, surely?

Silent Hill 3 has a great female protagonist imo, but you have to play Silent Hill 1 to get the gist of the story in 3.

Trying to find some that haven't been talked about yet:

Echo. It's a fantastic experimental infiltration game with an AI that adapts to your way of playing. The setup is very impressive.

Pathologic: one of the three playable characters (the Changeling). It's a bizarre russian game, with an unique world, and messy gameplay. Can't recommend it enough.

Va11 Hall-A: chill bartending game in a cyberpunk setup.

The Blackwell series: comfy, kind of amateurish point and clicks by Wadjet Eye. I like them very much.

Transistor: weirdest game by Supergiant. You play as a redhead with a talking sword. I don't remember much about it except that it was good.

The Fall: (pushing it a little bit, since the protagonist is an AI, but I've always seen here as female.) Criminally underrated puzzle games, disguised as metroidvanias.

Eliza (by Zachtronics): the only visual novel I enjoyed. It's hard to explain, it's about AI, burnout, whether tech dehumanizes people, and solitaire.

Hedon Duology: for something completely different, it's a slightly kinky retroshooter, with amazon Orcs fighting demons.
It may sound a bit dumb, but it's excellent. Huge levels, interesting worldbuilding, and a gameplay based on exploration, puzzles as well as shooting.

There's probably a ton more, but that's all I can think about at the moment.

Don't see it mentioned yet, it's an older game but Remember Me is pretty good

Cyberpunk!

Aquaria

A very well put together Metroidvania. The map is very fun to explore, good boss fights, great music, and interesting story.

It Takes Two has a great protagonist

The Mass Effect series is still my favorite, you can choose your protagonist to be female and the game will adapt accordingly. Or Dragon Age if you are more into fantasy.

Resident Evil Remake 2 and 3, great games with both male and female protagonists!

A group of developers have created a version of the game and it's sequels that runs on modern machines: http://nolfrevival.tk/

Edit: this was meant as a reply to @KIM_JONG_JUICEBOX 's comment. No One Lives Forever is a whip smart spy FPS that nails the Bond aesthetic but stars an unforgettable female protagonist, Kate Archer. Download it for free above.

Returnal is a great game if you like roguelite mechanics. Great gameplay, art design, and sound. The haptics on the PS5 are excellent too.

A few more that may not be mentioned:

Dandara - fun platformer

Ion Fury - throwback to 90s shooters, good if you can handle some juvenile humor.

Knights and Bikes - played through with my daughter and we loved it.

Spiritfarer - low pressure gameplay, story and exploration focused (edit: sorry, runekn already mentioned this one)

Some not yet mentioned.

• Heaven's Vault
• Mirror's Edge
• Portal 1 and 2 (technically, though she's mute and it's first person so not that it matters much)
• Slime Rancher
• Spiritfarer

How about Final Fantasy XIII? The first game has a full sized party, but Lightning is clearly the main character and the focus. Second game costars Lightning's younger sister and a new male character. Third game is just Lighting.

Stardew valley is fun

"good" is subjective, but I can recommend the Tomb Raider reboots.