Context: I like immersion and getting the most out of a game's systems.
I see someone said the opposite, but I'd recommend playing the one difficulty above normal. If you don't you'll barely ever need to interact with some parts of the game like the alchemy system.
Also the game lets you heavily customize the interface. I personally hate being led around by a dotted line/arrow, so if you feel the same know you can turn all of that off.