Looking up the first company listed, Fullers.
They made £60M Profits in their financial year ending March 2024 and paid ~14M in taxes in total, of which ~£8M of that is NI. The change to NI would take their total taxes up to approx. £15M (25% of their profits)
I can see how their hands are completely tied and it's completely impossible for them to continue to operate with their current workforce /s