I wonder what the implications for transplant recipients are.
this post was submitted on 16 Sep 2023
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Let's not put the cart before the horse.
... But also I'd like to point out that celiac is an autoimmune disease, so for some people this may be a vaccine against gluten free bread.
My son (who is 9) was diagnosed with celiac when he didn't grow from age 2-3 (gluten -> guts make enzyme to digest it -> immune system sees enzyme making cells as invaders -> immune system attacks cells -> intestines swell -> nutrition stops being absorbed). He was effectively starving despite eating. He's on track now as we have a strict gluten free household, and the fad people have created a market demand which makes companies want to make products that give him options...but a treatment like this would be life changing.
The good thing for him is that he was so young when he was diagnosed that he probably doesn't know anything else. Saying this from personal experience as I was diagnosed at 14 months in mid 80s. Of course, something like this would be amazing as I can't tolerate even small amounts of accidental gluten but as I don't know anything else I can't even imagine anything else.
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so for some people this may be a vaccine against gluten free bread
The most marvelous medicine in the history of humanity.
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"an inverse vaccine"
Oh good, at least they didn't choose a name that's gonna cause confusion.
TIL you can wait until you have the disease to take the vaccine. So if my kid gets polio, I'll give them the vaccine then, but I don't want to risk anything bad happening so I'll wait. I'm glad I did my research.
That naming does makes sense, given what the treatment does, although I agree they really need to work on their marketing and come up with a term that won't cause confusion or get the anti-vax folk excitable.
From the article:
"A typical vaccine teaches the human immune system to recognize a virus or bacteria as an enemy that should be attacked. The new “inverse vaccine” does just the opposite: it removes the immune system’s memory of one molecule. While such immune memory erasure would be unwanted for infectious diseases, it can stop autoimmune reactions like those seen in multiple sclerosis, type I diabetes, rheumatoid arthritis, or Crohn’s disease, in which the immune system attacks a person’s healthy tissues."
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"Inverse vaccine" sounds like instead of preventing a disease through a weakened or dead version of the thing you're preventing, they inject you with a stronger version of the thing you already have to kick it's ass.
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Notably they trialled first for coeliac autoimmune, but it'll be 2024 before phase 2 results are out for that. About 10 years back there was a similar vaccine which also passed phase 1 trials but failed at phase 2. Phase 1 is basically testing that the vaccine does no harm in small groups and it is phase 2 where they measure if it is actually efficacious and to what level. If it passes phase 2, then get your hopes up.
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As someone with Celiac disease with a women who also is celiac, this gives so much hope of living a normal life again.
Please happen !
... initial phase I safety trials have already been carried out in people with celiac disease ...
In case you happened to miss that part. Good luck!