Debian 12 and flatpak everything. I recently made the switch from Ubuntu and I couldn't be happier.
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I haven't tried it, but I suppose you'll do just fine with debian sid. i.e edit /etc/apt/sources.list, swap $distro_nickname for sid, sudo apt update, sudo apt full-upgrade.
I think WINE recommend an up to date distro due to rapidly changing stuff needing up to date software and kernel. I think Debian wouldn't be great for that. I'd personally recommend OpenSuse. Rolling, up to date and great with KDE. Good luck.
Depending on the games you wanna play it's probably safer to be somewhat closer to the bleeding edge than Debian would allow you to be. Nobara gets recommended so often because you get a good tradeoff between the newest updates and stability. Also KDE is their standard DE. PopOS is good if you wanna stay with apt, but comes with Gnome out of the box.