Being able to build vertically makes it a very different experience. Using a hyper tube chain to yeet yourself all the way across the map is chef's kiss.

The blueprints are helpful for mid to late game when you need to set up dozens of the same thing. It's not a perfect system, but can definitely be a time saver.

The combat is totally different. There's no raid/defense mechanism. The mobs have a fixed spawn point. They'll stop respawning once you start building around that point. Once you learn the appropriate attack/dodge maneuver for each type, they're barely even a nuisance to kill.

There's also a new 3D factory game called Foundry. Having bounced off of Satisfactory, that one seems more promising as a fan of Factorio.