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Do psychedelics really work to treat depression and PTSD? Here's what the evidence says
(theconversation.com)
General discussions about "science" itself
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People who support drug legalization or just like drugs in general and sign up for these trials may be incentivized to lie about their experience. Even if they subjectively experience no improvement in depression ("no placebo effect" situation), they might lie and say they did to make psychedelics look more useful. As the article says, it is hard to setup a double-blind experiment since the psychedelic effect is pretty unmistakable.