this post was submitted on 23 Feb 2024
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egg_irl β€” Memes about being trans people in denial and other eggy topics

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[–] [email protected] 60 points 6 months ago (3 children)

Will one pill by itself do anything? I thought it was more of a prolonged course of treatment.

[–] [email protected] 73 points 6 months ago (2 children)

It depends.

Yeah, you won't get any sort of externally visible changes from a single dose, but for some trans people that first dose can still be a life-changing experience.

They don't warn you about it in the informed consent documentation, but for me that first day on HRT brought on an almost overwhelming feeling of gender euphoria. It was like a part of myself that had been missing since puberty finally fell into place. The weight of 25 years of repressed dysphoria fell from my shoulders and I couldn't stop smiling, couldn't even walk across a room without breaking into a little dance.

It took the better part of a week to start seeing some physical changes, and that was mostly in skin texture.

[–] [email protected] 46 points 6 months ago* (last edited 6 months ago) (3 children)

Sounds like the euphoria could also be from feeling relief that you finally have access to it?

[–] [email protected] 28 points 6 months ago* (last edited 6 months ago) (2 children)

that's definitely part of it, but sex hormones interact with* neurotransmitters and the mental/emotional stuff tends to hit first, before any physical effects take place.

[–] [email protected] 11 points 6 months ago (1 children)

Not countering what you experienced, but sex hormones are not neurotransmitters. There may be some interactions with the neurotransmitter system but it they are not themselves.

[–] [email protected] 5 points 6 months ago

yep, that's more accurate ty!

[–] [email protected] 10 points 6 months ago

I think that part of it, for me at least, was that it felt like everything shifted and all of a sudden my brain was finally running right for the first time in my life. It’s like it was already wired to run on estrogen and I was finally giving it what it needed.

[–] [email protected] 10 points 6 months ago

That aspect of it was most definitely present, indeed.

[–] [email protected] 2 points 5 months ago

You absolutely can get some emotional benefits from the first dose before the physical ones start. I felt much more calm and less heightened emotions after my first dose of T. A welcome change having dealt with PMDD for years.

[–] [email protected] 20 points 6 months ago (2 children)

I tried to stay away from hrt but oof you're making it hard... That sounds amazing.

[–] [email protected] 33 points 6 months ago* (last edited 6 months ago)

It does! But I should mention that this experience isn't universal.

Some trans folks don't get the day-1 giddiness at all, instead finding that their baseline mood improves steadilly over the first few days or weeks of treatment without a period of euphoria.

Another common experience is a period of mild depression around 6-8 months in. For me, this was similar to the teenage moodiness of my first puberty, though much milder and less "wrong"-feeling.

[–] [email protected] 11 points 6 months ago

Go read through my posts if you want some more early days experiences.

[–] [email protected] 56 points 6 months ago (2 children)

I took one pill and my dick propelled off. It just flew off got damnit. I still miss it.

[–] [email protected] 15 points 6 months ago (1 children)
[–] [email protected] 9 points 6 months ago

YES I SHOULD HAVE BUT I DID NOT 😭

[–] [email protected] 7 points 6 months ago (1 children)

This is exactly why you are supposed to take the first pill under doctor supervision.

[–] [email protected] 6 points 6 months ago

Noone told me, I got it offered in a pub

[–] [email protected] 27 points 6 months ago (2 children)

there's a little voice in my head telling me to try one just to fuck around

[–] [email protected] 19 points 6 months ago (1 children)

Tbh, I'd be tempted to say "go for it!" if it weren't for the medical liability. A doc would want to check your hormone levels before prescribing estradiol just to ensure that there aren't any risk factors present.

The odds of one dose fucking you up are very, very low but not zero.

[–] [email protected] 13 points 6 months ago (1 children)

Not a doctor- but...

There's a reason E is normally prescribed with a testosterone blocker. Small doses of Estradiol will do next to nothing if there's still a natural level of T flowing through your system.

[–] [email protected] 13 points 6 months ago* (last edited 6 months ago) (2 children)

Trans enby here.

I've still got my "normal" levels of testostetone, but I'm taking finasteride to keep it from affecting my hair follicles while the estradiol does its work softening my skin and plumping up my chest.

I probably could be a lot more feminine by this point if I had a full-spectrum anti-androgen like spironolactone or cyproterone acetate, but that's not my transition goal. I'm actively seeking an androgynous appearance and itty bitty titties, so estradiol monotherapy with finasteride is working just fine for me.

[–] [email protected] 10 points 6 months ago (1 children)

Right, but in the context of

there’s a little voice in my head telling me to try one just to fuck around

Trying 'one just to fuck around' will do next to nothing.

[–] [email protected] 8 points 6 months ago (1 children)

Probably, yeah.

Though, I'd love to hear from a "cis guy" who decided to fuck around like this and found out something about themselves in the process. =3

[–] [email protected] 6 points 6 months ago (1 children)
[–] [email protected] 7 points 6 months ago

Legally I must state that it is not, but if you do go through with it then I want a trip report. =D

[–] [email protected] 6 points 6 months ago

I read "Plump up my chest" to the tune of "Pump up the Jam"

It's stuck in my head now πŸ˜‚

[–] [email protected] 3 points 5 months ago

A single Estradiol prolly won't do anything.

But testosterone blockers like Spironolactone is also a heart medication, so be careful.