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I don’t mix much, haven’t in years in fact, but the worst I ever got was just a really unattractive mud color when I was hoping to get a nice blue-green. In particular, FP inks should be similar enough in chemistry that switching colors without flushing shouldn’t do anything worse than make your first page of the new ink look bad.
Would love to hear stories that prove me wrong though. Wouldn’t be surprised at all if it happens fairly commonly.
Manufacturers usually have to cater to the lowest common denominator.
There are very good chances that there is a large group of people who have mixed the wrong kinds of ink together, damaged their pens &/or possessions then contacted them to complain & demand compensation.
99% of the time there should be no issues but with several thousand different inks they can't test every combination.
Worst reaction, although less of a reaction than clogging, was with Diamine glitter ink.
Worked fine with B-M nibs, but not mixed and certainly not with smaller nibs. Had to flush that out thoroughly.