Non-Political Memes

I was playing a little mobile game where a dog was howling at the moon out of loneliness, and you had to successfully do a thing to make the echo come back to the dog so he doesn't feel so alone. The first time I wasn't paying attention and failed and the dog was lonely and sad and I literally never played that game again. :(

Am I the only one that completely misses the point of the last panel?

Is this a reference to something??