I wasn't even using Wine. I installed it and launched through Steam and the entire process was as seamless as if it were on Windows. Valve is doing great work.

I didn't try MCC or multiplayer, since I was just performance testing on the computer (will eventually be the wife's machine after we move next month), but even running Academy with the bots was running great. I was able to sign into my Microsoft account no problem though, so I want to try multiplayer next.