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i've tried so many different SSRIs and SNRIs
they have all had 0 useful effect on me. i've experienced side effects; digestion issues are the most common. i got uncontrollable leg shaking from one of them. i've never experienced any withdrawal symptoms coming off them, but for most people they are quite bad.
when i was a kid i was put on fluoxetine, and it was just as unhelpful. i wanted to stop and they wouldn't let me, so a few months in, i quit them myself. some months later, my mother commented on how much better i seemed, how well the medication was working. i told her i hadn't been taking it, and she didn't believe me.
i'm now at a point where i absolutely refuse to touch them. the only thing that has actually had an impact on depression for me is ketamine.