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breathing oxygen is vital unlike marijuana and byproducts like free radicals are irrelevant since it's part of cell respiration, you can't live without oxygen while you can live without marijuana, also marijuana also produce free radicals in fact all living beings produce free radicals even fish who lives in water, oxygen in water and in air differs but both produce free radicals so what's the point of your arguments, sure let's say there's an increase of oxygen content in air in a limited area that produce free radicals much more it's not as deadly as MX3 and other supplements portrays it to be, Macrophages eat those even without an immune response, if they don't do that your entire body will be muddied with too much garbage
but I'm open to idea that there are pros, so what are they?, and are you sure they're free from publication bias
EDIT: add more clarifications
there is no such thing as unbiased publication, the best way is to look at all sides.
example sabi ko nga sa mga psychiatric problems https://jamanetwork.com/journals/jama/article-abstract/2338266
or sa negative impacts https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4827335/
and also marijuana is consumed not only by smoking, there are for example edibles
isa pa sa nadidismiss sa paglegalized is yung pwede na mag research legally once it is approved.
at yung number one kapag nalegalized is REGULATION.
a posible side effect din is most likely it will be alternative sa alcohol, which we know that in many cases could be dangerous, I'm not dismissing that cannabis is not dangerous. for example drunk driving is dangerous like high driving.
at lalo ng malaking effect kaya ako pabor sa legalization ng recreational use ay magiging safer alternative as compare to the likes of opium (shabu).
yung mga crime na patayan is ma lessen kasi why will you go for shabu kung may "legal" naman na marijuana. tapos regulated pa, it's not 100% full proof. but definitely I believe na ma lessen yung crime related sa drugs.
pain? big no, meditation and even a placebo can lessen or erase the pain.
psychiatric? could be but only for adults 25 and beyond, for me kids, teens, adolescence and early adults should be illegal to consume even as a medicinal but if the patient wants it, it should be strictly monitored and only do so when other options are wearied out already, remember Seroxat by GSK has made it to public fooling both FDA and Psychiatrist and Psychologist it is publicly believed to be okay to prescribed to adolescence and only stopped when Spitzer slams them
edibles are not safe either THC traces have some negative connotations surrounding it too and it's also the reason getting high is a thing
I agree with all but it cites DSM which is criticized for making homosexuality a mental disease before, and experimenting with grief exception.
well marijuana research is already happening, and it's result is the reason why it's still illegal.
I agree a bit since there's some truth to it but I won't encourage someone to try marijuana if they're not in some other extreme drugs, I'll only advise it to those who have addiction on much extreme drugs
EDIT: Seroxat(aka Paxil, Paroxetine) pala not Xeroxat
well in pain meditation/placebo is kinda borderline pseudo science, it's a mind over matter thing eh, it may effect or not, but if we take the route of protein interaction, madaling makita yung direct science sa effect nung substance sa dopamine, serotonin, endorphins, oxytocin and the likes.
sa recreational, it's tricky since it's prone to abuse, we don't know how to properly regulate it, so we are not ready for that, but when and if that time comes na okay na, I want to try it for once, para naman makaescape sa reality.
meditation is proven to increase pain tolerance, in placebo there's this American Anesthetist named Henry Beecher, during WWII they ran out of opiate-based painkillers so before the placebo he thought of trying inducing heart failure on utterly wounded soldiers but before doing so he tried gaslighting the soldiers they are taking morphine but what he gives is just a saltwater drip, well the result is the same as taking morphine.
I don't know about the protein interaction you're talking about, but if you're talking about hormones able to bind to any cell in your body and have its effects, then I already knew that, learnt it from Huberman, meditation increases serotonin level which is the body's natural pain killer so it's not unscientific.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2931548/
To be honest, I admit I can't understand it, now if you understood it explain in layman's terms, now if you expound this again,
you're trying to confuse me since dopamine lang ang nandoon sa source mo sa link, and dopamine is a pleasure hormone so it could be more about pleasure and less or not about pain