this post was submitted on 21 Aug 2023
53 points (84.4% liked)

Science

13261 readers
16 users here now

Subscribe to see new publications and popular science coverage of current research on your homepage


founded 5 years ago
MODERATORS
all 15 comments
sorted by: hot top controversial new old
[–] [email protected] 10 points 1 year ago (2 children)

1000mg is quite high for a single dose of paracetamol.

[–] [email protected] 3 points 1 year ago (1 children)

In the US, that’s the maximum single dose. What is it for your country?

[–] [email protected] 2 points 1 year ago (1 children)
[–] [email protected] 2 points 1 year ago

Just checked my medicine cabinet and my Acetaminophen bottle is 500mg per tablet. Ad. I've definitely taken two before. I might take less now.

[–] blur457 5 points 1 year ago (2 children)

(I didn't read the article) Is it the drug or is it the pain the drug is taken to alleviate? If I've got a headache or muscle soreness I'm more likely to focus on that than someones fee-fees.

[–] [email protected] 5 points 1 year ago

It's a controlled experiment, not a population study, so the acetaminophen sample weren't in more pain than the control group. But it's a relatively high dose, and while statistically significant the effect seems kind of small. I'm not sure there's really particularly big conclusions you can draw from it.

[–] [email protected] 2 points 1 year ago

Acetaminophen [...] blunts physical and social pain by reducing activation in brain areas thought to be related to emotional awareness and motivation.

[–] [email protected] -2 points 1 year ago (2 children)

Is that maybe why there been an uptick of bad people in the last couple of decades.

[–] [email protected] 7 points 1 year ago (1 children)

Acetaminophen doesn't exactly have a long lasting effect. And this is 1/4 of the maximum recommended daily dose administered at once. I think if people were regularly taking enough tylenol that it has a mass societal effect we'd be seeing a lot more liver failures.

[–] [email protected] 2 points 1 year ago (1 children)

Nar, probably the material systems rewarding such behaviors