I prefer to set up each program in its own Wine prefix if possible - each Wine prefix is like a new "install" of Windows. When they're all separated they don't have any chance of breaking each other when they need special configurations. If you run Wine without specifying a prefix, it will use your default system prefix. If you use e.g. WINEPREFIX="/arbitrary/path/to/a/prefix"
as an environment variable it will create a new prefix at that location.
You'll also want the winetricks package, which is probably in your distro's repos. Then you can run e.g. WINEPREFIX="/your/prefix" winetricks -q -f dotnet48 vcrun2022 dxvk vkd3d
to install DotNet stuff, Microsoft's C++ stuff, and DirectX->Vulkan translators. Installing these will solve a lot of potential issues for a Wine prefix right out of the box. After those are finished setting up, you can run your programs by declaring your WINEPREFIX before you call wine
, e.g. WINEPREFIX="/your/prefix" wine /your/program.exe
If you want to use a prefix manager to handle some of this for you, you can try Lutris or Bottles. Lutris is primarily built for gaming but it can handle regular applications all the same.
As for running specific programs, you probably want to search the internet to see if anyone else has run them in Wine and if they did anything special. Wine+dotnet48+vcrun2022+dxvk+vkd3d can get you a long way for compatibility, but it will quickly spiral into the bizarre if that doesn't work.